PARK, Soon Jae,박순재,CHUNG, Hye-Shin,정혜신,LEE, Sunbae,이선배
申请号：
KRKR2019/002911
公开号：
WO2019/177372A1
申请日:
2019.03.13
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to an antibody that specifically binds to folate receptor alpha (FOLR1) and thereby blocks the activity of FOLR1, and relates to a modified antibody that significantly enhances binding ability to an antigen by enhancing the binding ability of a conventional antibody. The modified antibody according to the present invention provided sequences in which the antigen binding site originally possessed by a parent antibody was replaced with amino acids that bind better with an antigen while retaining the basic structure of the parent antibody, thereby enhancing the binding ability with the antigen. In addition, the antibody or an antigen-binding fragment thereof according to the present invention can be used for the prophylactic or therapeutic use of cancer, and can be used for diagnosis of diseases. The modified antibody according to the present invention provides an amino acid-substituted sequence which better binds an antigen binding site originally possessed by a parent antibody to an antigen while retaining the basic structure of the parent antibody, thereby enhancing the binding ability with the antigen. In addition, the antibody or an antigen-binding fragment thereof according to the present invention can be used for the prophylactic or therapeutic use of cancer, and can be used for diagnosis of diseases.La présente invention concerne un anticorps qui se lie de manière spécifique au récepteur alpha du folate (FOLR1) et bloque ainsi l'activité de FOLR1, ainsi qu'un anticorps modifié permettant d'améliorer de façon significative la capacité de liaison à un antigène en améliorant la capacité de liaison d'un anticorps classique. L'anticorps modifié selon la présente invention concerne des séquences dans lesquelles le site de liaison à l'antigène possédé à l'origine par un anticorps parent a été remplacé par des acides aminés qui se lient mieux à un antigène tout en conservant la structure de base de l'anticorps parent, ce qui permet d'améli
