Ann Elizabeth Meyers,Anna-Lise Williamson,Edward Peter Rybicki,Emmanuel Aubrey Margolin,Rosamund Chapman
申请号：
US16382933
公开号：
US20190337994A1
申请日:
2017.10.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to a method for producing a recombinant HIV glycoprotein polypeptide in a plant and to trimeric complexes of the recombinant, plant-produced HIV glycoprotein polypeptide which mimic the native HIV Env complex. The invention also relates to nucleic acids encoding the recombinant polypeptides, expression vectors containing the aforementioned nucleic acids and to pharmaceutical compositions, uses and methods of eliciting an immune response against HIV in a subject using the recombinant polypeptides and trimeric complexes.
