RECOMBINANT NEURAMINIDASE AND USES THEREOF

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专利权人:

发明人:

Suh-Chin WU,Wen-Chun LIU,Chia-Ying LIN

申请号：

US14685286

公开号：

US20160067328A1

申请日:

2015.04.13

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A recombinant neuraminidase based on amino acid sequence (SEQ ID NO: 1) of wild-type pH1N1-NA (A/Texas/05/2009) influenza virus is provided. The recombinant neuraminidase of the present invention has an ectodomain with an amino acid sequence essentially identical to SEQ ID NO: 1 and replaced at specific positions 149, 344, 365 and 366 residue(s) with corresponding amino acids of other influenza viruses. The recombinant neuraminidase may incur cross-protective immunity and be used as universal influenza vaccine.

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