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THIENO[3,2-C]PYRIDINE DERIVATIVES AS KINASE INHIBITORS FOR USE IN THE TREATMENT OF CANCER
专利权人:
ABBOTT LABORATORIES
发明人:
MICHAELIDES, MICHAEL, R
申请号:
NZ59271409
公开号:
NZ592714A
申请日:
2009.12.04
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
Disclosed herein are the compounds: N-(4-{ 4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl} phenyl)-N -(3-fluorophenyl)urea; N-(4-{ 4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl} phenyl)-N'-[4-(difluoromethoxy)phenyl]urea; N-[4-(4-amino-7-{ 1-[(2S)-2-hydroxypropyl]-1H-pyrazol-4-yl} thieno[3,2-c]pyridin-3-yl)phenyl]N'-(3-methylphenyl)urea; N-(4-{ 4-amino-7-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl} phenyl)-N'-(4-methoxyphenyl)urea; and N-[4-(4-amino-7-{ 1-[(2S)-2,3-dihydroxypropyl]-1H-pyrazol-4-yl} thieno[3,2-c]pyridin-3-yl)phenyl]-N'-(4-methoxyphenyl)urea. Said compounds are useful as kinase inhibitors and as such is useful in the treatment of cancer.
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