БИЧ Эдвард (GB),РОДУЭЛЛ Олден (GB),СКВАЙРС Марк (GB)
申请号：
RU2013132210/15
公开号：
RU2013132210A
申请日:
2011.12.12
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A liquid composition comprising an aqueous solution of NSAIDs and one or more cyclodextrins. 2. The liquid composition of claim 1, wherein the NSAID is selected from the group consisting of ibuprofen, ketoprofen, flurbiprofen, diclofenac, naproxen. 3. A liquid composition according to claim 2, wherein the NSAID is selected from ketoprofen or flurbiprofen. A liquid composition according to any one of the preceding claims, wherein the cyclodextrin is selected from α, β, γ-cyclodextrin and its derivatives, including natural cyclodextrins and their derivatives, including alkyl and hydroxyalkylated derivatives and branched cyclodextrins, derivatives having sugar groups. 5. The liquid composition according to claim 1, wherein the cyclodextrin is selected from the group consisting of hydroxyethyl, hydroxypropyl (including 2- and 3-hydroxypropyl) and dihydroxypropyl esters, their corresponding mixed esters, as well as mixed esters with methyl or ethyl groups, such as methyl hydroxyethyl, ethyl hydroxyethyl and ethyl hydroxypropyl esters of α, β, γ-cyclodextrin. 6. The liquid composition of claim 5, wherein the cyclodextrin derivative is selected from the group consisting of methyl-α-cyclodextrin, hydroxyethyl-α-cyclodextrin, hydroxypropyl-α-cyclodextrin, dihydroxypropyl-α-cyclodextrin, methyl-β-cyclodextrin, hydroxyethyl-β- cyclodextrin, hydroxypropyl-β-cyclodextrin, dihydroxypropyl-β-cyclodextrin, methyl-γ-cyclodextrin, hydroxyethyl-γ-cyclodextrin, hydroxypropyl-γ-cyclodextrin and dihydroxypropyl-γ-cyclodextrin. 7. The liquid composition according to claim 1, in which the ratio of NSAIDs to cyclodextrin is from 1: 0.5 to 1: 1.5.8. The liquid composition according to claim 7, in which the ratio1. Жидкая композиция, включающая водный раствор НПВС и одного или более циклодекстринов.2. Жидкая композиция по п. 1, в которой НПВС выбирается из группы, включающей ибупрофен, кетопрофен, флурбипрофен, диклофенак, напроксен.3. Жидкая композиция по п. 2, в которой НПВС выбирается и
