Invention herewith described refers to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes compounds (I) according to claim 1 with N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate which is followed by the carbamoylation of the intermediate N-ethoxycarbonylmethyl-4(R)-aryl-2-pyrrolidinone with ammonia.Izum se odnosi na R-enantiomer N-karbamoilmetil-4-aril-2- pirolidinona (R-Karfedon) koji ima farmakološku vrednost. Metoda njegove pripreme uključuje jedinjenja (I) prema zahtjevu 1 pomoću N-alkilacije 4(R)-fenil-2-pirolidinona s etil bromacetatom koju sledi karbamoilacija intermedijarnog N-etoksikarbonilmetil-4(R)-aril-2-pirolidinon s amonijakom.
