N-carbamoylmethyl-4-(R)-phenyl-2-pyrrolidinone, method of its preparation and pharmaceutical use

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专利权人:

Joint Stock Company (JSC) “OLAINFARM”

发明人:

Grigory Veinberg,Maksim Vorona,Liga Zvejniece,Aleksandrs Chernobrovijs,Ivars Kalvinsh,Ligita Karina,Maija Dambrova

申请号：

US14688633

公开号：

US09382203B2

申请日:

2015.04.16

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.

来源网站：

中国工程科技知识中心

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