The present teaching relates to interactive medical image processing for surgical procedure planning. In one example, a three dimensional (3D) image of a kidney is obtained. The three dimensional image is rendered on a display screen. An input is received from a user specifying a location with respect to a representation of the kidney in the rendered three dimensional image. A representation of an instrument is rendered on the display screen based on the location. The instrument is automatically aligned with an infundibulum pathway of calyx at the location with respect to the kidney. A graphical line extension is rendered on the display screen to visualize the alignment of the instrument. One or more measurements related to the kidney are determined based on the location and an anatomical structure of the kidney.