Kankan, Rajendra Narayanrao,Rao, Dharmaraj Ramachandra,Srinivas, Pathi L.,Relekar, Jayamadhava P.
申请号：
AU2005298416
公开号：
AU2005298416B2
申请日:
2005.10.26
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention is concerned with a process for the preparation of 2n-butyl-4-spirocyclopentane-1-[(2'-(tetrazol-5-yl)biphenyl-4-yl) methyl]-2-imidazolin-5-one hydrochloride, irbesartan hydrochloride, novel hydrated and anhydrous crystalline forms thereof, amorphous irbesartan hydrochloride, formulations containing the same, therapeutic uses thereof and methods of treatment employing the same. The process of the present invention is a one-pot process which comprises reacting intermediate compounds 2n-butyl-1, 3-diazaspiro [4,4] non-1-en-4-one and 5-(4' -bromomethyl-biphenyl-2-yl)-1-trityl-lH-tetrazole.
