PROBLEM TO BE SOLVED: To provide methods of suppressing the immune tolerance of a disease in a patient, which are useful in treatment of cancers and infections.SOLUTION: A method comprises decreasing the immunosuppressive activity of Treg cells by administering a therapeutic composition comprising allogeneic Th1 cells to a patient, where decreasing and/or inhibiting the activity of the Treg cells suppresses immune tolerance of disease antigens in the patient. The therapeutic composition preferably further comprises IFN-γ, and also preferably further comprises components that interact with and reduce the activity of TGF-β.SELECTED DRAWING: Figure 1BCOPYRIGHT: (C)2016,JPO&INPIT【課題】癌及び感染症の治療に有用な、患者における疾患の免疫寛容を抑制する方法の提供。【解決手段】同種異系Ｔｈ１細胞を含む治療用組成物を患者に投与することにより、Ｔｒｅｇ細胞の免疫抑制活性を低減することを含み、前記Ｔｒｅｇ細胞の活性を低減及び／又は阻害により、前記患者における疾患抗原の免疫寛容を抑制する方法。前記治療用組成物はＩＦＮ－γをさらに含むことが好ましく、ＴＧＦ－βの活性と相互作用して、前記ＴＧＦ－βの活性を低下させる成分をさらに含むことも好ましい。【選択図】図１Ｂ
