ALLEN, DAVID GEORGE,COE, DIANE MARY,COOK, CAROLINE MARY,COOPER, ANTHONY WILLIAM JAMES,DOWLE, MICHAEL DENNIS,EDLIN, CHRISTOPHER DAVID,HAMBLIN, JULIE NICOLE,JOHNSON, MARTIN REDPATH,JONES, PAUL SPENCER,L
申请号：
CA2511340
公开号：
CA2511340C
申请日:
2003.12.19
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to a compound of formula (I) or a salt thereof: Formula(I) wherein: R1 is C1-4alkyl, C1-3fluoroalkyl or -(CH2)2OH； R2 is a hydrogenatom (H), methyl or C1fluoroalkyl； R3a is a hydrogen atom (H) or C1-3alkyl； R3is optionally substituted branched C3-6alkyl, optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl,optionally substituted phenyl, or an optionally substituted heterocyclic groupof sub-formula (aa), or (bb) or (cc) in which n1 and n2 independently are 1 or2； and Y is O, S, SO2, or NR4； and wherein Het is of sub-formula (i), or (ii),or (iii), or (iv) or (v). The compounds are phosphodiesterase (PDE)inhibitors, in particular PDE4 inhibitors. Also provided is the use of acompound of formula (I), or a pharmaceutically acceptable salt thereof, in themanufacture of a medicament for the treatment and/or prophylaxis of aninflammatory and/or allergic disease in a mammal such as a human, for examplechronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.
