The side effect is little, oral administration is possible, is widely used, at the same time, offers the cheap liver diseased remedy medicine. The liver diseased remedy medicine the derivative or designates the salt which that medicine of rifamycin B or rifamycin B reason it can allow as the active ingredient. When this liver diseased remedy medicine, is prescribed to the patient who contracts a disease in the liver disease, liver function is improved, ALT value and the AST value which are liver functional index decrease.副作用が少なく、経口投与ができ、汎用性が高く、且つ、安価な肝臓疾患治療剤を提供すること。肝臓疾患治療剤は、リファマイシンB若しくはリファマイシンBの誘導体又はその薬理的に許容しうる塩を有効成分とする。この肝臓疾患治療剤を、肝臓疾患に罹患する患者に投与すると、肝機能が改善され、肝機能の指標であるALT値、AST値が低下する。