Ltd.;Shenzhen City of Regeneration Biological Pharmaceutical Technology Co.
发明人:
Hui Zhang,Bingfeng Liu,Fan Zou
申请号：
US16322470
公开号：
US10633432B2
申请日:
2017.01.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a VC-CAR molecule and a use thereof in removing HIV-1 infected cells. The VC-CAR molecule is characterized by linking an HIV-1 broad-spectrum neutralizing antibody VRC01 sourced scFv sequence and an intracellular domain sequence of a conventional CAR molecule which are respectively used as extracellular and intracellular domains. A T cell modified by the VC-CAR molecule can be specifically activated and secrete a great number of cytotoxicity-related cytokines, so that lysis of a target cell can be powerfully mediated, and it can be better used for anti-infection adoptive immunotherapy.
