EMILY STANLEY,DARREN MARK LEGRAND,CHRISTOPHER THOMSON,OWEN HUGHES,VIKKI FURMINGER
申请号：
ARP130104878
公开号：
AR101428A1
申请日:
2013.12.19
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
1. The compounds referred to in this list are autocrine inhibitors, their preparation procedures, drugs and drugs containing such preparations, and drugs used to treat diseases or diseases mediated by ATX or ATX. 1. Claim 1: a formula compound (1),Or select the acceptable salt of prescription A from a set of formulas (2)；A selected from O, s and 7491；A selected from O and S； Y1 es - (CRS 7495； - 758080). - o-ch = ch -；X is selected from - C (= O),-N (R) -C (3DO) --C (3DO) -N (R) --N (R) - y -CH -Y es - (CR R) -m is selected from 0, 1, 2, 3, 4 and 5； n is selected from 0, 1, 2, 3, 4 and 5； where when Y¹ is - (CR²ᵇR²ᶜ) ₘ- and A is not HO-C (= O) -,The sum of M and N is not less than 2 and not more than 5； when y 1 is - 1 (cr. $7495； $758058) 8344； - A is = ho-c (= O),The sum of M and N is not less than 2 and not more than 7； or a-y1-x is an equation compound (3)；L select from a set of formulas (4)；W is ch or N； Z is selected from ch832222；O and 8309； 7580；Y3 was selected from - O - (cr8310； 7491； r8310； 74955)；- (CR R) -O--CH=CH---CR R -CR R -y -O- (CR R -CR R) -R74191,R74959,RS758080,R¹ᵈ and R¹ᵉ are defined according to any of (a) R¹ᵇ is halogen； R¹ᵈ is halogen, CN, C₁₋₄ alkyl, C₁₋₄ haloalkyl or C₁₋₄ haloalkoxy； and R¹ᵃ,R¹ᶜ and R¹ᵉ are H； (b) R¹ᵇ is halogen； R¹ᵈ is halogen, CN, C₁₋₄ alkyl, C₁₋₄ haloalkyl or C₁₋₄ haloalkoxy； R¹ᶜ is halogen； and R¹ᵃ and R¹ᵉ are H； (c) R¹ᵇ is C₁₋₄ alkyl； R¹ᵈ is C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ haloalkoxy or CN； R¹ᵃ,R¹ᶜ and R¹ᵉ are H； (d) R¹ᵇ is CN； R¹ᵈ is C₁₋₄ haloalkyl or C₁₋₄ haloalkoxy； and R¹ᵃ,R¹ᶜ and R¹ᵉ are H； (e) R¹ᵇ is C₁₋₄ haloalkyl or C₁₋₄ haloalkoxy； and R¹ᵃ,R7 758080 and R7 74977 are h； R1 7496es h or CN； (f) R7 74919 is halogen； RR 758080 is halogen, CN, c833218324aquilo, c83321c8318324halogeeo or c83318324haloxyl； R1 r74955；RS1 74969 and r7497son h； (g) RS1 758080 is halogen, CN, c8321；R¹ᵇ and R¹ᵉ are H； and R¹ᵈ is halogen, CN, C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ haloalkoxy, or H； R² is selected from H, C₁₋₄ alkyl and halogen
