The United States of America; Dept. of Health and Human Services; as represented by the Secretary
发明人:
Alan T. Remaley,Scott M. Gordon
申请号：
US16692849
公开号：
US20200078434A1
申请日:
2019.11.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Described herein is the design and construction of a class of lipoprotein targeting protease inhibitors. Small peptides with protease inhibitor activity are conjugated to hydrophobic, lipoprotein targeting molecules using, for instance, amine reactive chemistry. Methods of use of the resultant lipoprotein targeting protease inhibitor (antiprotease) molecules are also described. Also described is the production and use of protease inhibitor enriched HDL particles, as well as A1AT-peptide-enriched HDL particles, and their use in various therapeutic contexts.
