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METHOD FOR TESTING FOR, PREVENTING, AND TREATING INFECTIOUS DISEASE ASPERGILLUS FUMIGATUS, AND COMPOSITION
专利权人:
NATIONAL INSTITUTE OF INFECTIOUS DISEASES
发明人:
MIYAZAKI, YOSHITSUGU,YAMAGOE, SATOSHI,KAJIKAWA, MASUNORI,SUGIURA, MASAHITO,ITOH, REIKO,KUMAGAI, HIROTAKA
申请号:
EP11870979
公开号:
EP2743699A4
申请日:
2011.08.12
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
As a result of the analysis by an SST-REX method so as to identify a target molecule for treating and testing an Aspergillus fumigatus infection, a YMAF1 protein has been found out, which is mainly localized in the cell wall of Aspergillus fumigatus. Moreover, it has been found out that YMAF1 protein-deficient Aspergillus fumigatus has reduced spore-forming ability and pathogenicity. Further, it has been found out that the survival rate of experimental mice having aspergillosis (invasive Aspergillus model mice) is improved by preparing and administering an antibody against the YMAF1 protein. Furthermore, it has been found out that Aspergillus fumigatus can be detected with a favorable sensitivity by an ELISA system using the antibody.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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