APPLICATION OF PYRIMIDINE DERIVATIVES FOR TREATMENT OF EGFR-DEPENDENT DISEASES OR DISEASES WITH ACQUIRED RESISTANCE TO AGENTS AIMED AGAINST MEMBERS OF EGFR FAMILY

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专利权人:

НОВАРТИС АГ (CH)

发明人:

ГАРСИА-ЭЧЕВЕРРИА Карлос (CH),МАИРА Совё-Мишель (FR)

申请号：

RU2013132018/15

公开号：

RU2013132018A

申请日:

2013.07.10

申请国别(地区):

RU

年份:

2015

代理人:

摘要：

1. The use of a compound of formula II or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein W is CR or N, wherein R is selected from the group consisting of (1) hydrogen, (2) cyano, (3) halogen, (4) methyl, (5) trifluoromethyl, (6) sulfonamido group, R is selected from the group consisting of (1) hydrogen, (2) cyano group, (3) nitro group, (4) halogen, (5) substituted and unsubstituted alkyl, (6) substituted or unsubstituted alkenyl, (7 ) substituted or unsubstituted alkynyl, (8) substituted or unsubstituted aryl, (9) substituted or unsubstituted heteroaryl, (10) substituted or unsubstituted heterocyclyl, (11) substituted or unsubstituted cycloalkyl, (12) -COR, (13) -COR, (14) -CONRR, (15) -NRR, (16) -NRCOR, (17) -NRSOR, (18) -OCOR, (19) -OR, (20) -SR, (21) -SOR, (22) -SOR and (23) -SONRR, wherein R and R are independently selected from the group consisting of (a) hydrogen, (b) substituted and unsubstituted alkyl, (c) substituted and unsubstituted aryl, (d) substituted and unsubstituted heteroaryl, (e) substituted and unsubstituted heterocyclyl, and (e) substituted and unsubstituted cycloalkyl, R is selected from the group consisting of (1) hydrogen, (2) cyano, (3) nitro group, (4) halogen, (5) hydroxy group, (6) amino group, (7) substituted and unsubstituted alkyl, (8) -COR and (9) -NRCOR, p whereby R and R are independently selected from the group consisting of (a) hydrogen and (b) substituted and unsubstituted alkyl, R is selected from the group consisting of (1) hydrogen, (2) cyano, (3) nitro, (4) halogen, (5) substituted and unsubstituted alkyl, (6) substituted and unsubstituted alkenyl, (7) substituted and unsubstituted alkynyl, (8) substituted and unsubstituted aryl, (9) substituted and unsubstituted heteroaryl, (10) substituted and unsubstituted heterocyclyl, (11) substituted and unsubstituted cycloalkyl, (12) -COR, (13) -NRR, (14) -NRCOR, (15) -NRSOR, (16) -OR, (17) -SR, (18) -SOR, (19) -SOR and ( 20) -SONRR, wherein R and R are

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