PROBLEM TO BE SOLVED: To obtain a prophylactic/therapeutic agent for diseases, e.g. cardiac diseases, autoimmune diseases, inflammatory diseases, septic shocks, or the like, which shows ameliorated drug stability.SOLUTION: This emulsion composition is obtained by including a compound (I) represented by formula (1) [wherein, R shows a group represented by an aliphatic hydrocarbon group, an aromatic hydrocarbon group, a heterocyclic ring group or OR1 (R1 shows H or an aliphatic hydrocarbon group) or a group represented by formula (2) (R1b shows H or an aliphatic hydrocarbon group. R1c is same as R1b or different from R1b and shows H or an aliphatic hydrocarbon group). R0 shows H or an aliphatic hydrocarbon group. R shows a bonding hand in combination with R0. Ring A1 shows the group represented by (1) an aliphatic hydrocarbon group, (2) an aromatic hydrocarbon group or (3) OR1 (R1 shows same meaning as the above R1) and (4) a cycloalkene which may be substituted with 1-4 atoms selected from halogen atoms. Ar shows an aromatic hydrocarbon group. Cycloalkene shows the group represented by formula (3), (4) or (5) and (n) shows 1-4], its salt or its prodrug and adjusting it to the pH of less than about 6.COPYRIGHT: (C)2001,JPO【課題】薬物の安定性が改善された心疾患、自己免疫疾患、炎症性疾患、セプティックショック等の疾患の予防・治療剤を提供する。【解決手段】式【化1】[式中、Rは脂肪族炭化水素基、芳香族炭化水素基、複素環基、-OR1(R1はH又は脂肪族炭化水素基を示す)で表される基又は式【化2】(R1bはH又は脂肪族炭化水素基を、R1cはR1bと同一又は異なってH又は脂肪族炭化水素基を示す)で表される基を、R0はH又は脂肪族炭化水素基を、RとR0は一緒になって結合手を、環A1は(1)脂肪族炭化水素基、(2)芳香族炭化水素基、(3)-OR1(R1は前記と同意義を示す)で表される基及び(4)ハロゲン原子から選ばれる1~4個で置換されていてもよいシクロアルケンを、Arは芳香族炭化水素基を、式【化3】で表される基を、nは1~4を示す]で表される化合物(I)又はその塩あるいはそのプロドラッグを含有し、pHが約6以下に調整された乳化組成物。
