Université de Montréal;British Columbia Cancer Agency Branch;Fred Hutchinson Cancer Research Center
发明人:
SAUVAGEAU, Guy,HUMPHRIES, Keith Richard,KIEM, Hans-Peter,FARES, Iman,CHAGRAOUI, Jalila
申请号：
LT15841193
公开号：
LT3194602T
申请日:
2015.09.17
申请国别(地区):
LT
年份:
2020
代理人:
摘要：
Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are based on the use of pyrimido[4,5-b]indole derivatives. Cell-based compositions and methods useful for therapeutic indications amenable to treatment with gene therapies, including hematopoietic stem cell therapies, are also described.
