PROBLEM TO BE SOLVED: To provide a new vasodilating agent, a hypotensive agent or an NO (nitrogen monoxide) release-accelerating agent.SOLUTION: This vasodilating agent, the hypotensive agent or the NO (nitrogen monoxide) release-accelerating agent contains a polysulfated polysaccharide, especially a polysulfated mucopolysaccharide as an active ingredient.COPYRIGHT: (C)2003,JPO【課題】新規な血管拡張剤、降圧剤及びNO(一酸化窒素)遊離促進剤の提供【解決手段】多硫酸化多糖類、特に多硫酸化ムコ多糖類を有効成分として含む血管拡張剤、降圧剤及びNO(一酸化窒素)遊離促進剤。