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Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
专利权人:
Guenter Linz;Matthias Grauert;Peter Sieger;Rolf Schmid
发明人:
Guenter Linz,Peter Sieger,Matthias Grauert,Rolf Schmid
申请号:
US13457991
公开号:
US08664222B2
申请日:
2012.04.27
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallization in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
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