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COMBINATION THERAPIES AND METHODS OF USE THEREOF FOR TREATING CANCER
专利权人:
发明人:
Michael B. Yaffe,Jesse C. Patterson
申请号:
US15431312
公开号:
US20170216317A1
申请日:
2017.02.13
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Pharmaceutical compositions including an effective amount of an antiandrogen or androgen antagonist in combination with a Plk inhibitor and methods of use thereof for treating cancer are disclosed. Administration of the combination of the active agents can be effective to reduce cancer cell proliferation or viability in a subject with cancer to the same degree, or a greater degree than administering to the subject the same amount of either active agent alone. The active agents can be administered together or separately. Methods of selecting and treating subjects with cancers, particular prostate cancers including castration resistant prostate cancer, breast cancers, particularly androgen receptor positive breast cancers, and pancreatic cancers are also provided.
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