This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.本發明包括可離子化化合物及組合物及其使用方法。該等可離子化化合物可用於製備適用於生物藥劑及治療劑之奈米粒子組合物。更特定言之,本發明係關於用於提供奈米粒子以囊封活性劑、將該等活性劑傳遞及分佈至細胞、組織、器官及個體之化合物、組合物及方法。