PROCEDES PERMETTANT D'AMELIORER LE TRAITEMENT PAR BLOCAGE DU POINT DE CONTROLE IMMUNITAIRE EN MODULANT LE MICROBIOME

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专利权人:

THE UNIVERSITY OF TEXAS SYSTEM;BOARD OF REGENTS

发明人:

WARGO, JENNIFER,GOPALAKRISHNAN, VANCHESWARAN

申请号：

CA3038076

公开号：

CA3038076A1

申请日:

2017.09.27

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Provided herein are methods and compositions for the treatment of cancer by modulating the microbiome to enhance the efficacy of immune checkpoint blockade. The microbiome may be modulated by the administration of butyrate and/or butyrate-producing bacteria. Also provided herein are methods of determining a response to an immune checkpoint inhibitor by identifying if a subject has a favorable microbial profile.

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中国工程科技知识中心

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http://www.ckcest.cn/home/