MCKERRECHER DARREN,PLE PATRICK,HENNEQUIN LAURENT FRANCOIS ANDRE,STOKES ELAINE SOPHIE ELISABETH
申请号：
NO20111095
公开号：
NO332895B1
申请日:
2011.08.03
申请国别(地区):
NO
年份:
2013
代理人:
摘要：
It is described the use of the compound 4- (4-chloro-2- methylindol-5-yloxy)-6-methoxy-7- (3- (pyrrolidin-1- yl)propoxy)quinazoline or a pharmaceutically acceptable salt thereof and one or more therapeutic agents selected from (i) further anti-angiogenic agents that work by a different mechanism from the inhibition of VEGF receptors tyrosine kinase； (ii) cytostatic agents； (iii) antiproliferative/antineoplastic drugs and combinations thereof； (iv) biological response modifiers； and (v) the antibody； for manufacturing a medicament for providing an antiangiogenic and / or vascular permeability reducing effect in a warm-blooded animal such as human； and also for the manufacture of a medicament for the treatment of cancer in warm-blooded animal such as human. Cancer is a particularly colon, breast, prostate, lungs and skin.Det er beskrevet anvendelse av forbindelser ifølge formel (I), hvor ring C er en 8, 9, 10, 12 eller 13-leddet bisyklisk eller trisyklisk gruppe som eventuelt kan inneholde 1-3 heteroatomer valgt uavhengig fra O, N og S； Z er -O-, -NH-, -S-, -CH2- eller en direkte binding； n er 0-5； m er 0-3； R2 er hydrogen, hydroksy, halogen, cyano, nitro, trifluormetyl, C1-3alkyl, C1-3alkoksy, C1-3alkylsulfanyl, -NR3R4 (hvor R3 og R4, som kan være like eller forskjellige, hver er hydrogen eller C1-3alkyl), eller R5X1- (hvor X1 og R5 er som definert heri； R1 er hydrogen, okso, halogen, hydroksy, C1-4alkoksy, C1-4alkyl, C1-4alkoksymetyl, C1-4alkanoyl, C1-4halogenalkyl, cyano, amino, C2-5alkenyl, C2-5alkynyl, C1-3alkanoyloksy, nitro, C1-4alkanoylamino, C1-4alkoksykarbonyl, C1-4alkylsulfanyl, C1-4alkylsulfinyl, C1-4alkylsulfonyl, karbamoyl, N-C1-4alkylkarbamoyl, N,N-di-(C1-4alkyl)karbamoyl, aminosulfonyl, N-C1-4alkylaminosulfonyl, N,N-di(C1-4alkyl)aminosulfonyl, N-(C1-4-alkylsulfonyl)amino, N-(C1-4alkylsulfonyl)-N-(C1-4alkyl)amino, N,N-di(C1-4alkyl-sulfonyl)amino, en C3-7alkylenkjede koblet til to ring C karbonatomer, C1-4-alkanoylaminoC1-4alkyl, karboksy eller en gruppe
