Use of zd6474 with 5-fu or/and cpt-11 in the manufacture of medicaments for the treatment of cancer and pharmaceutical compositions and kits comprising the same
The present invention relates to a method for the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human, which is optionally being treated with ionising radiation, particularly a method for the treatment of a cancer, particularly a cancer involving a solid tumour, which comprises one of: the administration of ZD6474 in combination with 5-FU； the administration of ZD6474 in combination with CPT-11； and the administration of ZD6474 in combination with 5-FU and CPT-11； to a pharmaceutical composition comprising one of: ZD6474 and 5-FU； ZD6474 and CPT-11； and ZD6474 and 5-FU and CPT-11； to a combination product comprising one of: ZD6474 and 5-FU； ZD6474 and CPT-11； and ZD6474 and 5-FU and CPT-11, for use in a method of treatment of a human or animal body by therapy； to a kit comprising one of: ZD6474 and 5-FU； ZD6474 and CPT-11； and ZD6474 and 5-FU and CPT-11； to the use of one of: ZD6474 and 5-FU； ZD6474 and CPT-11； and ZD6474 and 5-FU and CPT-11, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation.Foreliggende oppfinnelse angår en metode for å frembringe en antiangiogen og/eller vaskulær permeabilitetsreduserende effekt hos et varmblodig dyr så som et menneske, som eventuelt behandles med ioniserende stråling, spesielt en metode for behandling av kreft, spesielt kreft som involverer en fast tumor, som omfatter én av: administrering av ZD6474 i kombinasjon med 5-FU； administrering av ZD6474 i kombinasjon med CPT-11； og administrering av ZD6474 i kombinasjon med 5-FU og CPT-11； et farmasøytisk preparat omfattende én av: ZD6474 og 5-FU； ZD6474 og CPT-11； og ZD6474 og 5-FU og CPT-11； et kombinasjonsprodukt omfattende én av: ZD6474 og 5-FU； ZD6474 og CPT-11； og ZD6474 og 5 -FU og CPT- I1, for anvendelse ved en metode for behandling av en m
