PHAN, Anh Tuan,LIM, Kah Wai,CHEONG, Vee Vee,LECH, Christopher Brian Henry Jacques,HEDDI, Brahim
申请号：
SG11201809002R
公开号：
SG11201809002RA
申请日:
2017.05.02
申请国别(地区):
SG
年份:
2018
代理人:
摘要：
The present invention relates to conjugates comprising (a) an antisense oligonucleotide (ASO) and (b) at least one G-quadruplex structure, wherein the ASO and the at least one G-quadruplex structure are heterologous to each other. The G-quadruplex of the conjugate may be further conjugated with ligands or functional moieties for addressable delivery and enhanced properties including potency and therapeutic index. Further encompassed are such conjugates for use as a medicament, a method of modulating the stability, translation, splicing, cleavage, or activity of a target nucleic acid molecule using such conjugates, and use of G-quadruplex in stabilizing antisense oligonucleotides.
