Van Roon-Mom, Wilhelmina Maria Clasina,Evers, Melvin Maurice,Pepers, Barry Antonius,Aartsma-Rus, Annemieke,Van Ommen, Garrit-Jan Boudewijn
申请号：
AU2011286539
公开号：
AU2011286539B2
申请日:
2011.08.04
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The invention relates to means and methods for removing a proteolytic cleavage site from a protein comprising providing a cell that expresses pre-m RNA encoding said protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that encodes said proteolytic cleavage site, the method further comprising allowing translation of m RNA produced from said pre-m RNA.
