compound, use of a compound, methods of prevention, treatment, amelioration or prophylaxis of physiological disorders or diseases, and treatment or amelioration of cosmetic indications, and, pharmaceutical composition
GUNNAR GRUE-SORENSEN,KRISTOFFER MANSSON,PER VEDSO,THOMAS HÖGBERG,XIFU LIANG
申请号：
BR112013015859
公开号：
BR112013015859A2
申请日:
2011.12.22
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The invention relates to compounds of general formula I, (I), wherein R is wherein R is aryl substituted by R3； or R is (C3-Ci3)-cycloalkyl, (C3-Ci3)-cycloalkenyl or (C7-Ci3)-cycloalkynyl optionally substituted by R4； and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use-alone or in combination with one or more other pharmaceutically active compounds-in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
