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DRUG FORM DESINTEGRATING IN ORAL CAVITY
专利权人:
MAKNEJLS-PPS; INK.
发明人:
BANIK Frehnk (US),БАНИК Фрэнк (US),LUBER Dzhozef (US),ЛУБЕР Джозеф (US),BANIK FREHNK,БАНИК Фрэнк,LUBER DZHOZEF,ЛУБЕР Джозеф
申请号:
RU2010121887/15
公开号:
RU0002482839C2
申请日:
2008.10.29
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions relates to field of pharmaceutics. Claimed is method of obtaining drug form, which include: a) placement inside depression of friable material, including at least approximately 5 wt % of at least one hydrated salt and pharmaceutically active agent, and where at least one hydrated salt is characterised by temperature of dehydration from 20 to 120°C; b) heating friable material in depression to temperature higher than said temperature of dehydration of at least one hydrated salt for time period sufficient for fusion of material with formation of aggregate, and heating is performed by radio-frequency or microwave heating; and c) cooling aggregate in depression until aggregate hardens in dosed form. Friable material can additionally contain carbohydrate. Claimed is drug form, obtained by said method. In order to obtain drug form, which includes external edible part and internal part, disintegrating in oral cavity, said friable material is placed inside depression in preliminarily created external edible form, with depression having required shape and volume, sufficient for placement of part of drug form, disintegrating in oral cavity.EFFECT: method makes it possible to create dosed drug forms avoiding production stage of pressing, which in its turn improves integrity of particles, which contain pharmaceutically active agent and are sensitive to forces of compression.16 cl, 3 tbl, 2 exГруппа изобретений относится к области фармацевтики. Предлагается способ получения лекарственной формы, включающий: а) размещение внутри углубления сыпучего материала, включающего по меньшей мере приблизительно 5% вес. по меньшей мере одной гидратированной соли и фармацевтически активный агент, и где по меньшей мере одна гидратированная соль характеризуется температурой дегидратации от 20 до 120°С; b) нагревание сыпучего материала в углублении до температуры, превышающей упомянутую температуру дегидратации по меньшей мере одной
来源网站:
中国工程科技知识中心
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