PHARMACEUTICAL COMBINATIONS COMPRISING B-RAF INHIBITOR, AND EGFR INHIBITOR AND OPTIONALLY PI3K-α INHIBITOR农业专利-农业学术服务平台

发明人:: GIORDANO CAPONIGRO,カポニグロ，ジョルダーノ,DARRIN STUART,スチュアート，ダリン,LAURE MOUTOUH-DE PARSEVAL,ムトゥ－ドゥパルスヴァル，ロール

摘要：: PROBLEM TO BE SOLVED: To provide a pharmaceutical combination used for the treatment of proliferative diseases.SOLUTION: The present invention provides a pharmaceutical combination comprising (a) a B-Raf inhibitor of the following formula, (b) an epidermal growth factor receptor (EGFR) inhibitor and, optionally, (c) a phosphatidylinositol 3-kinase (PI3K)-α inhibitor, for simultaneous, separate or sequential administration. There is also provided use of such a combination in the treatment of proliferative diseases.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】増殖性疾患の治療に使用される組合せ医薬の提供。【解決手段】同時投与、個別投与又は逐次投与のための、（ａ）下式のＢ－Ｒａｆ阻害薬、（ｂ）上皮成長因子受容体（ＥＧＦＲ）阻害薬、及び場合によっては（ｃ）ホスファチジルイノシトール３－キナーゼ（ＰＩ３Ｋ）－α阻害薬を含む組合せ医薬。増殖性疾患の治療におけるこのような組合せの使用。【選択図】なし