Svetlana O. Doronina,Toni Beth Kline,Scott Jeffrey,Peter D. Senter,Damon Meyer
申请号：
US11994459
公开号：
US08871720B2
申请日:
2006.07.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
