A surgical fastener applier includes a variable drive mechanism disposedwithin ahousing and operably coupled between an input member and an output member, thevariabledrive mechanism being transitionable between at least a first condition,wherein rotation of theinput member by a fixed amount effects rotation of the output member a firstamount, and asecond condition, wherein rotation of the input member by the fixed amounteffects rotation ofthe output member a second amount different from the first amount.