Sung-Wuk Kim,Sung-Soo Jun,Chang-Hee Min,Ja-Seong Koo,Jin-Wook Kim,Yong-Eun Kim,Sang-Ouk Sun
申请号：
US14004746
公开号：
US20140235559A1
申请日:
2011.06.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed is an anticancer pharmaceutical composition comprising phenformin or a pharmaceutically acceptable salt thereof, and 2-deoxy-D-glucose as active ingredients. These ingredients act in synergy with each other, thus exhibiting more potent inhibitory activity against the growth of cancer cells, compared to individual ingredients. Also, the synergistic anticancer activity allows the individual drugs to be used in lower amounts, which leads to a reduction in the occurrence of adverse effects. In addition, the time-lag release or administration of the ingredients decreases blood lactic acid levels to significantly mitigate the adverse effect of lactic acidosis, as well as exerting high anticancer effects. Particularly, the pharmaceutical composition can be formulated to dosage forms effective for therapy, increasing the drug compliance of the subject.
