MITRA ASHIM K U S A,VELAGALETI POONAM R U S A,GRAU ULRICH M U S A
申请号：
IN2587/MUMNP/2011
公开号：
IN2011MN02587A
申请日:
2011.12.02
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
Topical drug delivery systems for ophthalmic use including mixed nancmicellar formulations of water-insoluble drugs and methods of treating diseases affecting die posterior ocular segments are disclosed. In an embodiment, an aqueous opbmalmic solution includes nanomicelles in a physiologicaliy acceptable buffer, having a pH of 5.0 to 8.0, wherein a corticosteroid at a concentration from about 0.01 % w/v to about 1.00 % w/v is solubilized through entrapment in a mixed micellar hydrophobic core with a corona composed of bydrophilic chains extending from the hydrophobic core, wherein the nanomicelles comprise vitamin E TPGS at" a coricSfltration ranging front about 3.0 % w/v to about 5.0 % w/v stabilised widi octoxynol-40 at a concentration ranging from about 1,0 % w/v to about 3.0 % w/v.
