Ulrich M. Grau;Ashim K. Mitra;Poonam R. Velagaleti
发明人:
Ashim K. Mitra,Poonam R. Velagaleti,Ulrich M. Grau
申请号：
US12774600
公开号：
US09017725B2
申请日:
2010.05.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Topical drug delivery systems for ophthalmic use including mixed nanomicellar formulations of water-insoluble drugs and methods of treating diseases affecting the posterior ocular segments are disclosed. In an embodiment, an aqueous ophthalmic solution includes nanomicelles in a physiologically acceptable buffer, having a pH of 5.0 to 8.0, wherein a corticosteroid at a concentration from about 0.01% w/v to about 1.00% w/v is solubilized through entrapment in a mixed micellar hydrophobic core with a corona composed of hydrophilic chains extending from the hydrophobic core, wherein the nanomicelles comprise vitamin E TPGS at a concentration ranging from about 3.0% w/v to about 5.0% w/v stabilized with octoxynol-40 at a concentration ranging from about 1.0% w/v to about 3.0% w/v.
