HUANG, TUR FU,黄德富,黃德富,CHANG, CHIEN HSIN,张倩馨,張倩馨,CHUNG, CHING HU,锺镜湖,鍾鏡湖
申请号：
TW101121679
公开号：
TW201350500A
申请日:
2012.06.15
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The invention provides a peptide compound comprising an amino acid sequence of formula X2-Trp-X3-X4-X5, X1-X2-Trp-X3-X4-X5 or X1-X2-Trp-X3-X4 or a pharmaceutically acceptable salt thereof, wherein X1 is selected from the group consisting of: Arg (R), Lys (K), Gly (G), Ala (A), Val (V), Leu (L), Ile (I), Ser (S), Thr (T), Cys (C), Asn (N) and Gln (Q) X2 is selected from the group consisting of: Lys (K), dLys (dK), Arg (R), Gly (G), Ala (A), Val (V), Leu (L), Ile (I), Ser (S), Thr (T), Cys (C), Gln (Q), Asn (N), Glu (E) and Asp (D) X3 is selected from the group consisting of: Phe (F), Tyr (Y), Trp (W), Gly (G), Ala (A), Val (V), Leu (L), Ile (I), Ser (S), Thr (T), Cys (C), Met (M), Asn (N), Gln (Q), Glu (E) and Asp (D) X4 is selected from the group consisting of: Gly (G), Ala (A), Val (V), Leu (L), Ile (I), Ser (S), Thr (T), Cys (C), Gln (Q) and Asn (N) and X5 is selected from the group consisting of: Gly (G), Ala (A), Val (V), Leu (L), Ile (I), Ser (S), Thr (T), Cys (C), Phe (F), Tyr (Y), Trp (W), Met (M), Lys (K) and Arg (R).The invention also provides a pharmaceutical composition, comprising a peptide compound of the invention, and a pharmaceutically acceptable excipient or carrier.The invention further provides a method for inhibiting platelet aggregation, comprising administering an effective amount of a peptide compound or a pharmaceutical composition of the invention to a subject in need of such treatment.The invention also further provides a method for the prevention or treatment of thrombogenic diseases, comprising administering an effective amount of a peptide compound or a pharmaceutical composition of the invention to a subject in need of such treatment.本發明提供一種胜肽化合物,包含一式X2-Trp-X3-X4-X5、X1-X2-Trp-X3-X4-X5或X1-X2-Trp-X3-X4之胺基酸序列或其醫藥上可接受鹽,其中X1係選自由His(H)、Arg(R)、Lys(K)、Gly(G)、Ala(A)、Val(V)、Leu(L)、Ile(I)、Ser(S)、Thr(T)、Cys(C)、Asn(N)及Gln(Q)所組成之群組;X2係選自由Lys(K)、dLys(dK)、Arg(R)、Gly(G)、Ala(A)、Val(V)、Leu(L)、Ile(I)、Ser(S)、Thr(T)、Cys(C)、Gln(Q)、Asn(N)、Glu(E)及Asp(D)所組成之群組;X
