The present invention provides a device comprising stent or catheter containing biofilms of microorganisms useful in cancer therapy. The microorganisms may be attenuated in their virulence factors and with cloned genes encoding specific proteins with anticancer activity. The biofilm-containing devices may be encased in membranes that allow diffusion of proteins with molecular masses of 25, 50, 75 or 100 kDa but not live biofilm organisms.
