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Selective inhibitors that interfere with the interaction of FRS2 with fibroblast growth factor receptor for the prevention and treatment of cancer
专利权人:
ファーマスーティカル;リミテッド;ライアビリティー;“ロシアン;テクノロジーズ”;カンパニー
发明人:
チュリャディン,セルゲイ アレキセーヴィッチ,ビャホフ,ミハイル ユリエヴィッチ,チマフェイエフ,イリャ ヴァレリエヴィッチ,チュリャディン,セルゲイ アレキセーヴィッチ,ビャホフ,ミハイル ユリエヴィッチ,チマフェイエフ,イリャ ヴァレリエヴィッチ
申请号:
JP2017513314
公开号:
JP6365999B2
申请日:
2014.06.06
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
The invention relates to medicine and includes the use of inhibitors which selectively interfere with the interaction between a fibroblast growth factor receptor and FRS2, and with the interaction with other components of the FRS2 complex. Use of the selective inhibitors described in the present invention leads to a proven increase in anti-tumor efficacy relative to other inhibitors and monoclonal antibodies, a decrease in the toxicity of treatment, and the possibility of achieving complete blockage using a low agent concentration and of conducting long-term treatment. The advantage of the invention consists in the development of a novel class of medicinal agents for treating malignant neoplasms and other diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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