A medicine management method includes: a prescription generating step of generating a prescription direction; and a dispensation operation step of making dispensation information regarding dispensation correspond to a medicine container and a prescription code, to update management information of a dispensation managing section. The medicine management method includes a withdrawal operation step of specifying the medicine container that corresponds to a prescription code cancelled in accordance with the management information at the time of a cancellation of the prescription direction in the dispensation operation step, to direct a withdrawal process on the medicine container based upon cancellation information. An accurate medicine withdrawal is performed on the medicine container cancelled.