SWANTEK FITZGERALD, Jennifer L.,SCOTT, John,PARRISH, Karen,NAPIER, Spencer,LAMB, David James,KLICIC, Jasna,HOFFMANN, Matthias,DAHMANN, Georg,WALKER, Edward,MCCARTHY, Clive
申请号：
PE0016192016
公开号：
PE14272016A1
申请日:
2015.03.12
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Heteroaryl relates to compounds of formula (1) where a is n or CH, CH D, e and G are C o n C t is discontinuous The Double Bonds are a simple link or double M is - CH2 -, - O -, - NH -,Among others R3 is Methyl or Ethyl aryl r1 is C6 C10, among others.Preferred compounds are: (4R) - 4 - [(1R) - 1 - [6 - (3,4-dimethoxyphenyl) - 2-methyl - 4.3 - pyrazolo [c] pyridin-4-yl] oxietil] pyrrolidin-2-one (4R) - 4 - [(1R) - 1 - [6 - (1 - ter - butilpirazol - 4-yl) - 2 - Methyl pyrazolo [43 - C] pyridin-4-yl] oxietil] pyrrolidin-2-one among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of protein kinase Syk being useful in the treatment of COPD, Asthma, allergic rhinitisSE REFIERE A COMPUESTOS HETEROARILO DE FORMULA (1) DONDE A ES N O CH D ES CH E Y G SON C O N T ES C LOS ENLACES DOBLES DISCONTINUOS SON UN ENLACE SIMPLE O DOBLE M ES -CH2-, -O-, -NH-, ENTRE OTROS R3 ES METILO O ETILO R1 ES ARILO C6-C10, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (4R)-4-[(1R)-1-[6-(3,4-DIMETOXIFENIL)-2-METIL-PIRAZOLO[4,3-c]PIRIDIN-4-IL]OXIETIL]PIRROLIDIN-2-ONA (4R)-4-[(1R)-1-[6-(1-TER-BUTILPIRAZOL-4-IL)-2-METIL-PIRAZOLO[4,3-c]PIRIDIN-4-IL]OXIETIL]PIRROLIDIN-2-ONA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA QUINASA SYK SIENDO UTILES EN EL TRATAMIENTO DE ASMA, EPOC, RINITIS ALERGICA
