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COMPOSÉS MACROCYCLIQUES COMME INHIBITEURS DE LA KINASE TRK
专利权人:
Array Biopharma; Inc.
发明人:
申请号:
EP18208279.2
公开号:
EP3521291A1
申请日:
2011.05.13
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases;intermediates of formula IIused in the preparation of compounds of formula I and the compound for use in the treatment of the diseases mentioned above of the following formula:
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