Neurological disorders and diseases, such as Alzheimers disease, Huntingtons disease, Parkinsons disease, amyotrophic lateral sclerosis (ALS) and Downs syndrome, can be ameliorated or beneficially treated by administration of a formulation comprising an effective amount of a pyrone-indole derivative of formula (I)Ar—B—Ar′ (I)wherein AR represents an indole nucleus ring system:Ar′ represents an alpha-, beta- or gamma-pyrone nucleus ring system:and each of B, R1, R2, R3, R4, R1′ and R2′ are as defined herein.
