UNIVERSITY OF ROCHESTER;THE LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER;UNIVERSITY OF GUELPH
发明人:
NOTTER, ROBERT H.,WANG, ZHENGDONG,SCHWAN, ADRIAN L.,WANG, ZHONGYI,DAVY, JASON A.,WARING, ALAN J.,WALTHER, FRANS,GORDON, LARRY M.
申请号：
CA2658478
公开号：
CA2658478C
申请日:
2007.07.20
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.
