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Biarylisonicotinic acid derivative and pharmaceutical use thereof
专利权人:
キッセイ薬品工業株式会社
发明人:
滝川 靖,清水 和夫,飯塚 雅人,藤倉 秀紀,平栃 正博
申请号:
JP2010533907
公开号:
JP5580204B2
申请日:
2009.10.14
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
Provided is a compound that is useful for the prevention of and as a remedy for diseases attributable to abnormal plasma uric acid levels. The invention pertains to a biaryl isonicotinic acid derivative represented by formula (I), and prodrugs or salts thereof, which has xanthine oxidase and URAT1 inhibitory activity and is thus useful for the prevention of and as a remedy for diseases attributable to abnormal plasma uric acid levels. In formula (I), ring A is an aryl or a heteroaryl, R1 is a cyano, a trifluoromethyl, etc., R2 is H, fluorine, a C1-6 alkyl, a C1-6 alkoxy, etc., R3 is fluorine, chlorine, a hydroxyl group or a group represented by U-Y-Z (U represents a single bond or -O-, Y represents a C1-6 alkylene, etc., Z is H, a halogen, a hydroxyl group, a methoxy group, etc.), and n is 0-3.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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