The object of the present invention is to manufacture a microneedle device that can support more physiologically active substances per microneedle and can be administered to the microneedle. One aspect of the present invention provides a method for manufacturing a microneedle device, and the method includes a step of applying a coating liquid on the microneedles, the coating liquid including a physiologically active substance and a sulfated polysaccharide. The microneedle device manufactured by this method includes a substrate, microneedles arranged on the substrate, and a coating layer formed on the microneedle. The coating layer includes a physiologically active substance and a sulfated polysaccharide.本發明之目的在於製造一種每根微針可擔載更多的生理活性物質且可將其投予之微針裝置。本發明之一形態提供一種製造微針裝置之方法，且其具備於微針上塗佈塗佈液之步驟，塗佈液包含生理活性物質及硫酸化多糖。藉由該方法製造之微針裝置具備：基板、配置於基板上之微針及形成於微針上之塗層，塗層包含生理活性物質及硫酸化多糖。
