MANZOOR KOYAKUTTY,RANJITH RAMACHANDRAN,GIRIDHARAN L., M.,SHANTIKUMAR V NAIR
申请号：
ININ2013/000144
公开号：
WO2014/141289A1
申请日:
2013.03.12
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The present invention is related to a core-shell photo-chemo nanomedicine aiding sequential or simultaneous delivery of a photosensitizer drug and at least one chemotherapeutic drug for combinatorial photodynamic therapy and chemotherapy of cancer. The nanomedicine core is made up of a biodegradable or biocompatible polymer and the shell is either by polymer or a protein aiding the following two configurations (i) polymer core-polymer shell and (ii) polymer core-protein shell. The core-shell nanomedicine is made in such a way that, while the core is loaded with photosensitizer, the shell will be loaded with a chemo-drug or vice-versa. Along with improving drug solubility, stability, bioavailability and therapeutic efficiency, the core-shell nanomedicine platform aids sequential or simultaneous delivery of photosensitizer and chemo drugs to cancer type diseases and thereby facilitates the application of photodynamic reactive oxygen stress together with or followed by chemotherapy. In addition, this core-shell nanomedicine can be targeted specifically to the disease site by conjugating with targeting molecules such as antibodies, peptides, small molecules, vitamins, proteins, etc. This core-shell photo-chemo nanomedicine system is capable of excreting photodynamic reactive oxygen stress together with or followed by chemotherapy.La présente invention porte sur un nanomédicament de photochimiothérapie à structure cœur-écorce facilitant ladministration séquentielle ou simultanée dun médicament photosensibilisateur et dau moins un médicament de chimiothérapie pour une thérapie photodynamique et une chimiothérapie combinées dun cancer. Le cœur du nanomédicament est constitué dun polymère biodégradable ou biocompatible et lécorce est soit en polymère soit en protéine avec lune des deux configurations suivantes : (i) cœur de polymère-écorce de polymère et (ii) cœur de polymère-écorce de protéine. Le nanomédicament à structure cœur-écorce est formé de façon à ce que, lorsque
