PROBLEM TO BE SOLVED: To provide populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes.SOLUTION: The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population. The progenitors can be further differentiated in culture into a variety of different neural phenotypes, including dopaminergic neurons. The differentiated cell populations or the neural progenitors can be generated in large quantities for use in drug screening and the treatment of neurological disorders.COPYRIGHT: (C)2013,JPO&INPIT【課題】神経前駆細胞、分化したニューロン、グリア細胞、およびアストロサイトの集団を提供する。【解決手段】幹細胞集団(胚性幹細胞など)を、分化を惹起し、神経前駆細胞集団を確立する成長条件の混液中で培養する。前駆細胞を培養下で、ドーパミン作動性ニューロンを含むさまざまな異なる神経表現型へとさらに分化させる。分化細胞集団または神経前駆細胞を、薬物スクリーニングおよび神経疾患の治療に用いるために大量に作製する。【選択図】なし
