To provide isolated human lung progenitor cells and a use thereof.SOLUTION: Provided are isolated human Nkx 2.1 positive Sox 2 positive proximal airway pluripotent progenitor cells that are proliferative and under selected differentiation conditions differentiate into respiratory tract basal stem cells, ciliated cells, clara cells, neuroendocrine cells, or squamous epithelial cells. Also provided are isolated human Nkx 2.1 positive Sox 9 positive distal pluripotent lung progenitor cells etc. that are proliferative and under selected differentiation conditions differentiate into epithelial lung cells.SELECTED DRAWING: Figure 1【課題】単離ヒト肺前駆細胞の提供およびその使用。【解決手段】増殖性であり、選択された分化条件で、気道基底幹細胞、繊毛細胞、クララ細胞、神経内分泌細胞、または扁平上皮細胞へと分化する、単離ヒトNkx2.1陽性Sox2陽性近位気道複能性前駆細胞。また、増殖性であり、選択された分化条件に置かれると任意の上皮肺細胞へと分化する、単離ヒトNkx2.1陽性Sox9陽性遠位複能性肺前駆細胞など。【選択図】図１
