A transition monitor receives data from a variety of sensors that provide data indicative of the level of sedation of a patient, such as a bispectral index monitor, automated responsiveness monitor, pulse oximeter, or other device. As data is received from a sensor device, the transition monitor will apply a weighting calculation and algorithm to the received value in order to determine a weighted value for the received data. The weighted value is used, along with prior values, to determine a sedated patients position within a continuum of sedation levels, such as minimal sedation, moderate sedation, or deep sedation. When a newly received value triggers a transition from one sedation level to a next sedation level, one or more thresholds, safeguards, or drug delivery configurations may be modified to adapt to the change within the sedation continuum.